Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa

High postprandial hyperglycaemia is an important determinant of the development and progression type 2 diabetes. Thus, inhibition key digestive enzymes such as α-amylase α-glucosidase considered efficient approach to control glycaemic levels in diabetics. In search inhibitors, root bark Paeonia suffruticosa was screened for resulting isolation eleven phenolic compounds (1–11). Their inhibitory activities mechanism were investigated using vitro assay molecular docking studies. Compounds 2, 5, 6, 8–11 (IC50 between 290 431 µM) inhibited more effectively than reference compound acarbose = 1463.0 ± 29.5 µM). However, > 800 less effective against 16.6 0.9 Among them, 10 exhibited highest effect with IC50 value 290.4 9.6 µM. 9 11 found be competitive while 6 8 noncompetitive inhibitors α-glucosidase. Computational analyses showed that main binding forces residues hydrogen bonds. The results suggest these have potential developed inhibitors.